RGN

Across TCGA cell cohorts, RGN mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RGN-associated genes across cancer lineages are BHLHE23, OR52E8, and PNLIPRP2. Each is linked with RGN in more than 1 cancer types. Because this analysis shows association rather than direction, both RGN-to-partner and partner-to-RGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by RGN-low versus RGN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGN→partner) and Y-score (partner→RGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BHLHE23 →	+0.049	+6.022	<.001	.001	3	1
SKIN	OR52E8 →	+0.032	+5.415	<.001	.004	3	1
BLOOD_Leukemia	PNLIPRP2 →	+0.678	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

BHLHE23 by RGN expression — SKIN

Explore this box plot interactively →