RFX3

Across TCGA patient cohorts, RFX3 mutation is significantly associated with the RNA expression of many other genes, with 1,361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX3-associated genes across cancer lineages are RN7SL248P, LINC02854, and RN7SL586P. Each is linked with RFX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX3-to-partner and partner-to-RFX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by RFX3-low versus RFX3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX3→partner) and Y-score (partner→RFX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL248P →	+0.087	+5.000	<.001	.003	3	3
HNSC	LINC02854 →	+0.046	+4.636	<.001	.006	3	3
CESC	RN7SL586P →	+0.124	+5.201	<.001	.007	3	2
LUSC	RNA5S9 →	+0.158	+5.102	.006	.002	3	2
BRCA	RNU6-519P →	+0.495	+3.856	.003	.005	3	2
BRCA	LINC02276 →	+0.313	+4.045	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,361 associations by consensus.

RN7SL248P by RFX3 expression — LUAD

Explore this box plot interactively →