RFX3

Across TCGA pan-cancer cohorts, RFX3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RFX3 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RFX3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RFX3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

BRCA, SCLC, and UVM are the cancer types where RFX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.949	0.897	<.001	98	view →
SCLC	OS	Median	All	0.782	0.505	<.001	67	view →
UVM	DFS	Tertile	III,IV	0.241	0.780	.006	33	view →
READ	OS	Median	II,III,IV	0.973	0.845	.002	30	view →
KIRC	OS	Quartile	All	0.752	0.577	.001	28	view →
GBM	DFS	Tertile	All	0.423	0.168	.002	24	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
LIHC	OS	Median	All	0.713	0.845	.010	24	view →
THYM	DFS	Median	II,III,IV	0.946	0.510	.005	22	view →
SKCM	OS	Quartile	III,IV	0.743	0.558	.011	21	view →
PRAD	DFS	Tertile	All	0.926	0.797	.017	12	view →
COAD	DFS	Median	III,IV	0.574	0.782	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

RFX3–BRCA (OS)

Open the BRCA breakdown →