RFX3

Across TCGA pan-cancer cohorts, RFX3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RFX3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RFX3 RNA is repressed in tumor relative to normal tissue. In most cancer types RFX3 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, COAD, and STAD are the cancer types where RFX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.910	<.001	8	view →
COAD	Male	All	+0.507	<.001	8	view →
STAD	All	II,III,IV	+0.728	<.001	7	view →
LIHC	All	II,III,IV	+0.471	<.001	7	view →
KICH	Female	All	−1.207	<.001	6	view →
LUAD	Female	II,III,IV	−0.873	<.001	6	view →
THCA	All	All	−0.388	<.001	6	view →
CHOL	Male	All	+1.500	<.001	5	view →
HNSC	Male	III,IV	+0.541	.003	4	view →
READ	All	III,IV	+0.945	.024	2	view →
PRAD	All	All	+0.867	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RFX3–LUSC

Open the LUSC breakdown →