REST

Across TCGA patient cohorts, REST mutation is significantly associated with the RNA expression of many other genes, with 2,952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REST-associated genes across cancer lineages are CD8A, FUT10, and ZNF683. Each is linked with REST in more than 2 cancer types. Because this analysis shows association rather than direction, both REST-to-partner and partner-to-REST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8A grouped by REST-low versus REST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REST→partner) and Y-score (partner→REST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8A →	+1.206	+2.828	<.001	<.001	3	3
UCEC	FUT10 →	+0.477	+2.513	<.001	<.001	3	3
UCEC	ZNF683 →	+0.855	+2.584	<.001	.001	3	3
BLCA	GCNT1P2 →	+0.131	+3.558	<.001	.005	3	2
LUSC	RNU4ATAC15P →	+0.213	+4.082	<.001	<.001	3	2
LUSC	MIR4666B →	+0.246	+4.099	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,952 associations by consensus.

CD8A by REST expression — UCEC

Explore this box plot interactively →