REST

Across TCGA pan-cancer cohorts, REST RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of REST’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where REST RNA is more highly expressed in tumor relative to normal tissue. In most cancer types REST is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where REST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.665	<.001	10	view →
LIHC	All	All	+0.430	<.001	7	view →
KIRC	Male	II,III,IV	−0.452	.002	6	view →
BRCA	All	II,III,IV	+0.400	<.001	6	view →
LUSC	All	All	+0.411	<.001	5	view →
CHOL	Male	All	+1.743	<.001	3	view →
STAD	All	II,III,IV	+0.514	.018	3	view →
KICH	All	All	−0.506	.011	2	view →
LUAD	All	All	+0.239	.018	2	view →
ESCA	Female	All	+0.683	.003	1	view →
COAD	Male	All	+0.329	.044	1	view →
KIRP	Male	All	−0.329	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

REST–HNSC

Open the HNSC breakdown →