REST

Across TCGA pan-cancer cohorts, REST RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated REST data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher REST RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated REST expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UCS, and CESC are the cancer types where REST RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.707	0.550	<.001	92	view →
UCS	DFS	Median	IV	0.952	0.367	.001	60	view →
CESC	DFS	Quartile	All	0.669	0.851	.004	54	view →
LGG	OS	Median	All	0.337	0.592	<.001	54	view →
THYM	DFS	Tertile	All	0.826	0.615	.005	28	view →
HNSC	DFS	Median	All	0.695	0.551	<.001	28	view →
PAAD	OS	Quartile	All	0.251	0.593	.009	25	view →
LUSC	DFS	Median	III,IV	0.405	0.884	.006	24	view →
MESO	OS	Tertile	III,IV	0.294	0.500	.008	22	view →
ACC	DFS	Tertile	All	0.579	0.837	.006	19	view →
READ	OS	Tertile	IV	0.933	0.491	.006	16	view →
SKCM	DFS	Tertile	All	0.267	0.163	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

REST–KIRC (DFS)

Open the KIRC breakdown →