RECK

Across TCGA cell cohorts, RECK mutation is significantly associated with the RNA expression of many other genes, with 456 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RECK-associated genes across cancer lineages are MBD3L4, ODF1, and ANKRD30BL. Each is linked with RECK in more than 1 cancer types. Because this analysis shows association rather than direction, both RECK-to-partner and partner-to-RECK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L4 grouped by RECK-low versus RECK-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECK→partner) and Y-score (partner→RECK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MBD3L4 →	+0.020	+4.087	<.001	.009	3	1
SKIN	ODF1 →	+0.016	+4.437	<.001	.004	3	1
SKIN	ANKRD30BL →	+0.078	+3.684	<.001	.006	3	1
SKIN	TEKT1 →	+0.055	+3.930	.003	.003	3	1
LARGE_INTESTINE	JOSD1 →	+0.585	+3.364	.002	.002	3	1
LARGE_INTESTINE	CGRRF1 →	+0.593	+3.169	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 456 associations by consensus.

MBD3L4 by RECK expression — URINARY_TRACT

Explore this box plot interactively →