Q-omics provides the consensus-scored MBD3L4 profile across patient tissues and cancer cell-line models. MBD3L4 expression is associated with patient survival in 3 of 34 cancer types, with the highest sampling consensus in CESC. Additionally, MBD3L4 RNA expression shows 5,997 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight CESC, and ESCA as cancer lineages where MBD3L4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for MBD3L4 — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes MBD3L4 survival associations across molecular data types. MBD3L4 RNA expression shows survival associations in the most cancer types (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

MBD3L4 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	3	CESC (144)	view →

This table ranks reproducible MBD3L4 RNA expression–survival associations across cancer types. High MBD3L4 expression shows unfavorable associations in CESC, ESCA and ACC. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify CESC as the clearest survival context for MBD3L4 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.091	0.875	<.001	144	view →
ESCA	OS	Tertile	II,III,IV	0.280	0.707	.012	36	view →
ACC	DFS	Tertile	All	0.140	0.666	.049	9	view →

Pink = unfavorable, green = favorable. all 3 lineages →

MBD3L4-CESC (OS)

Kaplan–Meier survival curve for MBD3L4 RNA expression in CESC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with MBD3L4 in patient tissues and cancer cell lines. In patient samples, MBD3L4 shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set. In cancer cell lines, MBD3L4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	5,997	ESCA (2805)	view →
Function (RNA)	1,803	STAD (1581)	view →

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	374	OESOPHAGUS (56)	view →
Mutation	98	LUNG_NSCLC_LUAD (30)	view →