Across TCGA pan-cancer cohorts, MBD3L4 RNA is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated MBD3L4 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher MBD3L4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MBD3L4 expression acts as an unfavorable survival marker.

CESC, ESCA, and ACC are the cancer types where MBD3L4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.091	0.875	<.001	144	view →
ESCA	OS	Tertile	II,III,IV	0.280	0.707	.012	36	view →
ACC	DFS	Tertile	All	0.140	0.666	.049	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MBD3L4 tumor-vs-normal RNA expression · all MBD3L4 data types