RECK

Across TCGA pan-cancer cohorts, RECK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RECK’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RECK RNA is repressed in tumor relative to normal tissue. In most cancer types RECK is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and BLCA are the cancer types where RECK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RECK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.491	<.001	11	view →
COAD	Female	II,III,IV	−1.017	<.001	10	view →
BLCA	Male	IV	−2.672	<.001	8	view →
LUSC	Female	II,III,IV	−2.057	<.001	8	view →
THCA	Male	III,IV	−1.170	<.001	8	view →
KICH	Female	All	−1.250	<.001	7	view →
UCEC	All	All	−2.200	<.001	6	view →
BRCA	All	All	−1.288	<.001	6	view →
STAD	All	All	−0.832	.003	5	view →
READ	Female	All	−1.628	.002	2	view →
LIHC	Female	All	+0.437	.021	2	view →
HNSC	Female	III,IV	+0.875	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RECK–LUAD

Open the LUAD breakdown →