RBPJ

Across TCGA patient cohorts, RBPJ mutation is significantly associated with the RNA expression of many other genes, with 1,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBPJ-associated genes across cancer lineages are HLTF-AS1, MED28P4, and MIR4774. Each is linked with RBPJ in more than 2 cancer types. Because this analysis shows association rather than direction, both RBPJ-to-partner and partner-to-RBPJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HLTF-AS1 grouped by RBPJ-low versus RBPJ-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPJ→partner) and Y-score (partner→RBPJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HLTF-AS1 →	+0.099	+5.685	<.001	.003	3	3
READ	MED28P4 →	+0.394	+5.039	<.001	.008	3	2
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
HNSC	RN7SL509P →	+0.087	+4.327	<.001	.009	3	2
BLCA	ZNF92P1Y →	+0.056	+7.307	<.001	<.001	3	2
UCEC	FANCA →	+0.514	+1.928	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,158 associations by consensus.

HLTF-AS1 by RBPJ expression — BLCA

Explore this box plot interactively →