RBPJ

Across TCGA pan-cancer cohorts, RBPJ RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RBPJ’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RBPJ RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBPJ is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where RBPJ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBPJ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.093	<.001	11	view →
KIRC	All	IV	+0.482	<.001	11	view →
LIHC	Female	II,III,IV	+1.020	<.001	9	view →
BLCA	Male	All	−0.713	.002	6	view →
CHOL	Male	All	+1.998	<.001	5	view →
THCA	All	All	−0.277	<.001	5	view →
BRCA	Female	All	−0.285	<.001	4	view →
STAD	All	II,III,IV	+0.595	.008	3	view →
UCEC	All	All	−0.406	.012	2	view →
LUSC	Male	All	−0.319	.007	2	view →
LUAD	Male	All	+0.295	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RBPJ–HNSC

Open the HNSC breakdown →