RBPJ

Across TCGA pan-cancer cohorts, RBPJ RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated RBPJ data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RBPJ RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RBPJ expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, MESO, and UVM are the cancer types where RBPJ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.928	0.748	<.001	90	view →
MESO	OS	Tertile	All	0.174	0.428	.004	88	view →
UVM	OS	Median	III,IV	0.378	0.909	<.001	86	view →
LIHC	DFS	Quartile	All	0.428	0.657	<.001	52	view →
SKCM	OS	Tertile	All	0.380	0.229	<.001	49	view →
KICH	DFS	Quartile	II,III,IV	0.284	0.874	.003	45	view →
LGG	OS	Median	All	0.865	0.747	<.001	35	view →
HNSC	DFS	Quartile	All	0.523	0.325	.002	33	view →
KIRP	DFS	Median	III,IV	0.149	0.665	.005	27	view →
THCA	OS	Tertile	All	0.978	1.000	.003	26	view →
CHOL	OS	Median	All	0.864	0.212	.010	26	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

RBPJ–UCEC (DFS)

Open the UCEC breakdown →