RBIS

Across TCGA patient cohorts, RBIS mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBIS-associated genes across cancer lineages are RNU1-83P, SIGLEC31P, and RNU1-6P. Each is linked with RBIS in more than 1 cancer types. Because this analysis shows association rather than direction, both RBIS-to-partner and partner-to-RBIS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-83P grouped by RBIS-low versus RBIS-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBIS→partner) and Y-score (partner→RBIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-83P →	+0.208	+5.669	<.001	.003	3	2
CESC	SIGLEC31P →	+0.118	+5.418	<.001	.005	3	2
CESC	RNU1-6P →	+0.284	+5.969	<.001	.002	3	2
SKCM	RN7SKP228 →	+0.199	+5.970	<.001	.002	3	2
UCEC	RNA5SP205 →	+0.599	+3.852	<.001	.002	3	2
COAD	RNU7-176P →	+0.537	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

RNU1-83P by RBIS expression — CESC

Explore this box plot interactively →