RBIS

Across TCGA pan-cancer cohorts, RBIS RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RBIS data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RBIS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RBIS expression acts as an unfavorable survival marker, although some lineages such as SKCM and THYM show a favorable association.

KIRC, UVM, and KICH are the cancer types where RBIS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.533	0.720	<.001	166	view →
UVM	DFS	Tertile	III,IV	0.180	0.854	<.001	102	view →
KICH	DFS	Tertile	III,IV	0.169	0.913	.001	76	view →
KIRP	DFS	Tertile	All	0.761	0.931	<.001	68	view →
ACC	OS	Quartile	All	0.709	0.967	.001	50	view →
LIHC	OS	Quartile	All	0.367	0.666	<.001	47	view →
HNSC	DFS	Tertile	All	0.523	0.658	.003	45	view →
UCEC	DFS	Median	All	0.568	0.712	<.001	40	view →
CESC	OS	Median	IV	0.305	0.768	.003	30	view →
LGG	DFS	Median	All	0.784	0.879	<.001	19	view →
PRAD	DFS	Median	All	0.894	0.970	<.001	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RBIS–KIRC (DFS)

Open the KIRC breakdown →