RAP1GDS1

Across TCGA patient cohorts, RAP1GDS1 mutation is significantly associated with the RNA expression of many other genes, with 2,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1GDS1-associated genes across cancer lineages are BOLA3P3, RN7SKP43, and MRPS36P3. Each is linked with RAP1GDS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAP1GDS1-to-partner and partner-to-RAP1GDS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BOLA3P3 grouped by RAP1GDS1-low versus RAP1GDS1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1GDS1→partner) and Y-score (partner→RAP1GDS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BOLA3P3 →	+0.247	+4.039	.003	.001	3	3
LUSC	RN7SKP43 →	+0.184	+5.151	.004	.007	3	2
LUSC	MRPS36P3 →	+0.348	+5.978	<.001	.002	3	2
LGG	CCER1 →	+0.018	+5.148	<.001	.007	3	2
SKCM	KRT8P28 →	+0.043	+3.300	<.001	.004	3	2
UCEC	MIR6766 →	+0.177	+2.037	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,357 associations by consensus.

BOLA3P3 by RAP1GDS1 expression — LUAD

Explore this box plot interactively →