RAP1GDS1

Across TCGA pan-cancer cohorts, RAP1GDS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RAP1GDS1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RAP1GDS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAP1GDS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

UVM, MESO, and KIRC are the cancer types where RAP1GDS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.266	0.721	<.001	93	view →
MESO	OS	Tertile	All	0.248	0.532	<.001	79	view →
KIRC	DFS	Tertile	All	0.724	0.529	<.001	50	view →
HNSC	OS	Median	IV	0.332	0.691	<.001	42	view →
LIHC	OS	Median	All	0.616	0.757	<.001	40	view →
LGG	DFS	Median	All	0.680	0.796	<.001	30	view →
READ	DFS	Quartile	II,III,IV	0.809	0.261	.004	30	view →
SKCM	OS	Quartile	III,IV	0.828	0.601	.009	21	view →
ACC	DFS	Quartile	All	0.565	0.834	.012	20	view →
BRCA	OS	Median	IV	0.742	0.345	.011	18	view →
THYM	OS	Median	II,III,IV	0.960	0.622	<.001	17	view →
SCLC	OS	Median	All	0.482	0.912	.028	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RAP1GDS1–UVM (DFS)

Open the UVM breakdown →