RAP1GDS1

Across TCGA pan-cancer cohorts, RAP1GDS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RAP1GDS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAP1GDS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAP1GDS1 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where RAP1GDS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP1GDS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.704	<.001	12	view →
COAD	All	II,III,IV	+0.510	<.001	9	view →
LIHC	Male	II,III,IV	+0.934	<.001	6	view →
BRCA	All	II,III,IV	+0.608	<.001	6	view →
CHOL	All	All	+1.087	.001	3	view →
READ	All	II,III,IV	+0.330	.022	3	view →
LUAD	All	All	+0.189	.003	3	view →
UCEC	All	III,IV	+0.733	.041	2	view →
STAD	All	II,III,IV	+0.418	.025	2	view →
KIRP	Male	All	−0.334	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RAP1GDS1–HNSC

Open the HNSC breakdown →