PYGB

Across TCGA patient cohorts, PYGB protein abundance is significantly associated with the RNA expression of many other genes, with 9,859 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PYGB-associated genes across cancer lineages are ASPM, ENTPD6, and SUV39H1. Each is linked with PYGB in more than 5 cancer types. Because this analysis shows association rather than direction, both PYGB-to-partner and partner-to-PYGB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGB versus ASPM in GBM, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGB→partner) and Y-score (partner→PYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ASPM →	-1.145	-0.266	.001	.006	3	6
LSCC	ENTPD6 →	+0.589	+0.526	.001	<.001	3	5
HNSC	SUV39H1 →	-0.587	-0.431	<.001	.001	3	5
GBM	SKA3 →	-1.001	-0.270	<.001	.003	3	5
OV	KPNA2 →	-0.798	-0.560	<.001	<.001	3	5
LUAD	PRR11 →	-0.812	-0.376	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,859 associations by consensus.

PYGB vs ASPM — GBM

Explore this scatter interactively →