PYGB

Across TCGA pan-cancer cohorts, PYGB RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PYGB data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PYGB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PYGB expression acts as an unfavorable survival marker, although some lineages such as LGG and UVM show a favorable association.

LUSC, MESO, and BLCA are the cancer types where PYGB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.728	0.821	<.001	105	view →
MESO	OS	Quartile	All	0.251	0.533	.001	100	view →
BLCA	DFS	Tertile	All	0.224	0.674	<.001	70	view →
LUAD	OS	Tertile	III,IV	0.476	0.808	<.001	53	view →
KIRC	DFS	Tertile	All	0.784	0.897	<.001	53	view →
OV	OS	Median	All	0.813	0.867	.001	48	view →
PAAD	DFS	Median	All	0.196	0.378	.001	46	view →
LIHC	DFS	Median	All	0.465	0.614	<.001	37	view →
LGG	DFS	Median	All	0.798	0.669	<.001	32	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	28	view →
UVM	DFS	Quartile	III,IV	0.898	0.266	.009	23	view →
COAD	OS	Median	II,III,IV	0.866	0.678	.003	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PYGB–LUSC (OS)

Open the LUSC breakdown →