PYGB

Across TCGA pan-cancer cohorts, PYGB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PYGB’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PYGB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYGB is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

LIHC, KIRP, and BLCA are the cancer types where PYGB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYGB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+2.330	<.001	9	view →
KIRP	All	II,III,IV	+1.395	<.001	9	view →
BLCA	All	III,IV	−1.601	.003	8	view →
LUAD	All	All	+0.306	.002	7	view →
HNSC	All	All	+0.673	.001	6	view →
CHOL	Male	All	+4.193	<.001	5	view →
STAD	Male	II,III,IV	+1.284	.004	5	view →
KICH	Female	II,III,IV	+1.242	<.001	5	view →
LUSC	Male	All	+0.614	<.001	4	view →
BRCA	Female	II,III,IV	−0.538	<.001	4	view →
KIRC	All	II,III,IV	−0.439	.002	4	view →
PAAD	All	All	+0.882	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PYGB–LIHC

Open the LIHC breakdown →