PWWP2A

Across TCGA patient cohorts, PWWP2A mutation is significantly associated with the RNA expression of many other genes, with 4,891 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWWP2A-associated genes across cancer lineages are SENP3-EIF4A1, RPL17-C18orf32, and RN7SL414P. Each is linked with PWWP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PWWP2A-to-partner and partner-to-PWWP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3-EIF4A1 grouped by PWWP2A-low versus PWWP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2A→partner) and Y-score (partner→PWWP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SENP3-EIF4A1 →	+0.167	+2.386	<.001	<.001	3	2
COAD	RPL17-C18orf32 →	+0.107	+3.010	<.001	.006	3	2
COAD	RN7SL414P →	+0.448	+3.698	<.001	.003	3	2
COAD	RN7SL303P →	+0.373	+3.865	<.001	.002	3	2
UCEC	LINC01943 →	+0.344	+1.748	.004	.002	3	2
UCEC	C14orf119 →	+0.245	+2.721	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,891 associations by consensus.

SENP3-EIF4A1 by PWWP2A expression — UCEC

Explore this box plot interactively →