PWWP2A

Across TCGA pan-cancer cohorts, PWWP2A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PWWP2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PWWP2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PWWP2A is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where PWWP2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PWWP2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.750	<.001	12	view →
LIHC	Female	II,III,IV	+1.025	<.001	9	view →
HNSC	All	All	+0.334	.001	6	view →
BRCA	All	II,III,IV	+0.237	.001	6	view →
STAD	All	II,III,IV	+0.583	.002	4	view →
CHOL	Male	All	+1.808	<.001	3	view →
LUAD	All	All	+0.281	.001	3	view →
BLCA	All	All	+0.291	.040	2	view →
UCEC	All	All	−0.287	.048	2	view →
COAD	All	All	−0.257	.008	2	view →
KIRP	Male	All	−0.296	.033	1	view →
ESCA	Female	All	−0.273	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PWWP2A–KIRC

Open the KIRC breakdown →