Prader-Willi region non-protein coding RNA 1Genealiases: LOHAN1 · NCRNA00198
Q-omics provides the consensus-scored PWRN1 profile across patient tissues and cancer cell-line models. PWRN1 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, PWRN1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, PWRN1 RNA expression shows 14,819 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UCS, KIRC, and GBM as cancer lineages where PWRN1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PWRN1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PWRN1 survival associations across molecular data types. PWRN1 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PWRN1 RNA expression–survival associations across cancer types. High PWRN1 expression shows unfavorable associations in UCEC, but favorable associations in UCS, LIHC, ESCA, LUAD and READ. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .012). Together, the overview and detailed table identify UCS as the clearest survival context for PWRN1 RNA expression.
This table summarizes PWRN1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for PWRN1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PWRN1 shows lower tumor expression in KIRC, KIRP, KICH, COAD, BRCA and STAD. The KIRC box plot shows higher PWRN1 RNA expression in normal versus tumor tissue (log2 FC = −0.664, t-test p < 0.001).
This table shows molecular features associated with PWRN1 in patient tissues and cancer cell lines. In patient samples, PWRN1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
