PWRN1

Across TCGA pan-cancer cohorts, PWRN1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PWRN1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PWRN1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PWRN1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LIHC show a favorable association.

UCS, LIHC, and ESCA are the cancer types where PWRN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	III,IV	0.569	0.273	.012	54	view →
LIHC	DFS	Median	All	0.551	0.285	<.001	51	view →
ESCA	DFS	Median	II,III,IV	0.450	0.272	.010	43	view →
LUAD	DFS	Tertile	III,IV	0.749	0.264	.004	29	view →
UCEC	DFS	Median	All	0.798	0.865	.011	24	view →
READ	OS	Median	III,IV	0.813	0.283	.001	22	view →
LUSC	DFS	Median	All	0.309	0.444	.011	20	view →
BLCA	DFS	Quartile	II,III,IV	0.702	0.586	.016	20	view →
SKCM	DFS	Tertile	IV	0.045	0.477	.005	18	view →
KIRP	OS	Tertile	All	0.964	0.873	.013	14	view →
COAD	OS	Tertile	All	0.827	0.600	.025	12	view →
ACC	OS	Quartile	IV	1.000	0.397	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PWRN1–UCS (DFS)

Open the UCS breakdown →