PWRN1

Across TCGA pan-cancer cohorts, PWRN1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PWRN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PWRN1 RNA is repressed in tumor relative to normal tissue. In most cancer types PWRN1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where PWRN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PWRN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.664	<.001	12	view →
KIRP	Male	All	−0.934	<.001	9	view →
KICH	All	All	−0.910	<.001	9	view →
COAD	Female	All	−0.077	<.001	9	view →
BRCA	All	All	−0.051	<.001	6	view →
STAD	All	All	−0.045	.001	6	view →
LUSC	Male	II,III,IV	−0.087	<.001	5	view →
UCEC	All	All	−0.301	.002	4	view →
THCA	Male	IV	−0.403	.042	1	view →
CHOL	Male	All	−0.078	.004	1	view →
LIHC	Female	All	−0.072	.010	1	view →
LUAD	All	III,IV	−0.027	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PWRN1–KIRC

Open the KIRC breakdown →