PTX3

Across TCGA patient cohorts, PTX3 mutation is significantly associated with the RNA expression of many other genes, with 1,608 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTX3-associated genes across cancer lineages are RNU6-12P, OR13Z3P, and HMGB1P32. Each is linked with PTX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTX3-to-partner and partner-to-PTX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-12P grouped by PTX3-low versus PTX3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTX3→partner) and Y-score (partner→PTX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-12P →	+0.465	+4.591	<.001	.004	3	2
HNSC	OR13Z3P →	+0.130	+6.936	<.001	<.001	3	2
COAD	HMGB1P32 →	+0.204	+5.588	<.001	<.001	3	2
COAD	CNN2P11 →	+0.170	+4.962	<.001	.003	3	2
COAD	CDC27P2 →	+0.106	+4.037	<.001	.004	3	2
COAD	CXCL1P1 →	+0.250	+4.730	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,608 associations by consensus.

RNU6-12P by PTX3 expression — LUSC

Explore this box plot interactively →