Q-omics provides the consensus-scored RNU6-12P profile across patient tissues and cancer cell-line models. RNU6-12P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, RNU6-12P is differentially expressed in 4, with the highest sampling consensus in ESCA. Additionally, RNU6-12P RNA expression shows 5,697 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight SKCM, ESCA, and HNSC as cancer lineages where RNU6-12P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-12P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-12P survival associations across molecular data types. RNU6-12P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-12P RNA expression–survival associations across cancer types. High RNU6-12P expression shows unfavorable associations in SKCM, UVM, ACC, COAD and LUAD, but favorable associations in LUSC. The SKCM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for RNU6-12P RNA expression.
This table summarizes RNU6-12P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-12P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-12P shows lower tumor expression in ESCA, THCA and PRAD and higher tumor expression in BRCA. The ESCA box plot shows higher RNU6-12P RNA expression in normal versus tumor tissue (log2 FC = −0.535, t-test p < 0.001).
This table shows molecular features associated with RNU6-12P in patient tissues and cancer cell lines. In patient samples, RNU6-12P shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set.
