PTX3

Across TCGA pan-cancer cohorts, PTX3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PTX3 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PTX3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTX3 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

CESC, KIRC, and KIRP are the cancer types where PTX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.660	0.852	<.001	108	view →
KIRC	DFS	Tertile	All	0.517	0.673	<.001	106	view →
KIRP	DFS	Median	II,III,IV	0.315	0.736	<.001	101	view →
UCEC	DFS	Median	All	0.573	0.709	<.001	88	view →
HNSC	OS	Tertile	All	0.583	0.745	<.001	77	view →
LUSC	OS	Median	All	0.332	0.478	<.001	76	view →
UCS	DFS	Median	III,IV	0.631	0.212	<.001	68	view →
BLCA	OS	Quartile	II,III,IV	0.639	0.786	<.001	57	view →
THCA	OS	Median	All	0.888	0.993	<.001	54	view →
MESO	OS	Median	All	0.270	0.508	<.001	53	view →
LGG	OS	Median	All	0.737	0.879	<.001	47	view →
KICH	DFS	Quartile	III,IV	0.221	1.000	.007	47	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PTX3–CESC (DFS)

Open the CESC breakdown →