PTEN

Across TCGA cell cohorts, PTEN mutation is significantly associated with the RNA expression of many other genes, with 1,869 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTEN-associated genes across cancer lineages are SIPA1L2, THRA, and SHFL. Each is linked with PTEN in more than 3 cancer types. Because this analysis shows association rather than direction, both PTEN-to-partner and partner-to-PTEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIPA1L2 grouped by PTEN-low versus PTEN-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTEN→partner) and Y-score (partner→PTEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SIPA1L2 →	+1.134	+2.459	<.001	.006	3	3
LARGE_INTESTINE	THRA →	+1.010	+3.064	<.001	.009	3	3
CNS	SHFL →	+0.773	+1.253	.001	.001	3	3
LARGE_INTESTINE	ZNF428 →	+0.901	+3.212	<.001	.006	2	4
CNS	THAP8 →	+0.523	+1.584	<.001	<.001	3	3
CNS	CZIB →	+0.355	+2.770	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,869 associations by consensus.

SIPA1L2 by PTEN expression — CNS

Explore this box plot interactively →