PTEN

Across TCGA pan-cancer cohorts, PTEN RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PTEN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PTEN RNA is repressed in tumor relative to normal tissue. In most cancer types PTEN is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where PTEN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTEN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.404	<.001	8	view →
HNSC	Female	III,IV	+0.817	.001	8	view →
THCA	Male	All	−0.489	<.001	8	view →
COAD	Female	All	−0.754	<.001	7	view →
UCEC	All	All	−1.084	<.001	6	view →
LUAD	Female	II,III,IV	−0.553	.003	4	view →
BRCA	Female	All	−0.379	<.001	4	view →
LUSC	All	All	−0.295	.004	3	view →
READ	All	All	−0.446	.014	2	view →
BRCA	All	IV	+0.355	.023	2	view →
PRAD	All	All	−0.294	.022	2	view →
KIRC	All	All	+0.223	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PTEN–KICH

Open the KICH breakdown →