PTEN

Across TCGA pan-cancer cohorts, PTEN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PTEN data layer compared with 12 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PTEN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTEN expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

ACC, SKCM, and KIRC are the cancer types where PTEN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.241	0.614	<.001	93	view →
SKCM	OS	Quartile	All	0.836	0.677	<.001	76	view →
KIRC	OS	Median	All	0.713	0.552	<.001	71	view →
SCLC	OS	Median	All	0.592	1.000	.007	35	view →
LGG	OS	Quartile	All	0.914	0.823	.003	20	view →
UCEC	DFS	Tertile	III,IV	0.833	0.704	.032	20	view →
MESO	OS	Tertile	IV	0.715	0.257	.006	15	view →
ESCA	DFS	Tertile	III,IV	0.559	0.237	.004	15	view →
LUSC	OS	Median	All	0.348	0.461	.011	15	view →
KICH	DFS	Quartile	II,III,IV	0.177	0.907	.020	11	view →
HNSC	DFS	Quartile	IV	0.490	0.231	.006	11	view →
THCA	OS	Median	II,III,IV	0.935	1.000	.020	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PTEN–ACC (DFS)

Open the ACC breakdown →