PSMA4

Across TCGA patient cohorts, PSMA4 mutation is significantly associated with the RNA expression of many other genes, with 2,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA4-associated genes across cancer lineages are MIR378E, RNA5SP416, and RN7SL248P. Each is linked with PSMA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA4-to-partner and partner-to-PSMA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR378E grouped by PSMA4-low versus PSMA4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA4→partner) and Y-score (partner→PSMA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR378E →	+0.331	+4.399	<.001	.006	3	2
UCEC	RNA5SP416 →	+0.749	+2.224	<.001	.009	3	2
UCEC	RN7SL248P →	+0.086	+3.722	<.001	.001	3	2
LUAD	RPL23AP54 →	+0.138	+5.410	<.001	.005	3	2
LIHC	OR5AK1P →	+0.052	+5.647	<.001	.004	3	1
LIHC	TSPAN9-IT1 →	+0.067	+5.355	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,129 associations by consensus.

MIR378E by PSMA4 expression — COAD

Explore this box plot interactively →