PSMA4

Across TCGA pan-cancer cohorts, PSMA4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PSMA4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSMA4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMA4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where PSMA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.049	<.001	12	view →
KIRC	Male	IV	+0.656	<.001	12	view →
STAD	Female	All	+1.037	<.001	11	view →
BLCA	Male	All	+0.940	<.001	11	view →
LIHC	Male	II,III,IV	+0.971	<.001	9	view →
LUSC	Female	All	+0.830	<.001	6	view →
UCEC	All	II,III,IV	+0.801	.002	6	view →
BRCA	All	III,IV	+0.646	<.001	6	view →
KIRP	Male	II,III,IV	+0.376	.005	6	view →
KICH	Female	All	−0.758	<.001	5	view →
LUAD	All	All	+0.325	<.001	5	view →
ESCA	All	All	+1.173	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PSMA4–HNSC

Open the HNSC breakdown →