PRDM6

Across TCGA patient cohorts, PRDM6 mutation is significantly associated with the RNA expression of many other genes, with 1,201 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM6-associated genes across cancer lineages are MIR6854, DUX4L52, and MIR6780B. Each is linked with PRDM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM6-to-partner and partner-to-PRDM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6854 grouped by PRDM6-low versus PRDM6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM6→partner) and Y-score (partner→PRDM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6854 →	+0.489	+4.575	<.001	.009	3	2
BRCA	DUX4L52 →	+0.123	+6.160	<.001	<.001	3	2
UCEC	MIR6780B →	+0.238	+2.211	.001	.007	3	2
UCEC	RNU6-22P →	+0.232	+2.029	.001	.007	3	2
UCEC	RNA5SP496 →	+0.492	+2.459	<.001	<.001	3	2
COAD	RN7SL275P →	+0.220	+5.080	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,201 associations by consensus.

MIR6854 by PRDM6 expression — BRCA

Explore this box plot interactively →