PRDM6

Across TCGA pan-cancer cohorts, PRDM6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PRDM6’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PRDM6 RNA is repressed in tumor relative to normal tissue. In most cancer types PRDM6 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LUSC, and THCA are the cancer types where PRDM6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRDM6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.607	<.001	11	view →
LUSC	Male	II,III,IV	−1.173	<.001	9	view →
THCA	Female	II,III,IV	−0.526	<.001	9	view →
LUAD	Female	III,IV	−0.975	<.001	8	view →
COAD	All	II,III,IV	−0.600	<.001	6	view →
READ	All	All	−1.761	.001	5	view →
KIRC	Male	All	−0.152	.002	4	view →
KICH	All	All	−0.299	.001	3	view →
LIHC	All	All	+0.126	.009	3	view →
UCEC	All	All	−0.608	.001	2	view →
PRAD	All	All	−0.493	.001	2	view →
CHOL	All	All	+0.431	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PRDM6–BLCA

Open the BLCA breakdown →