PRDM6

Across TCGA pan-cancer cohorts, PRDM6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PRDM6 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PRDM6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRDM6 expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

UVM, KIRP, and ACC are the cancer types where PRDM6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.286	0.721	.001	88	view →
KIRP	OS	Median	II,III,IV	0.241	0.705	.001	62	view →
ACC	OS	Quartile	All	0.752	1.000	<.001	58	view →
LGG	DFS	Median	All	0.637	0.830	<.001	54	view →
THCA	OS	Tertile	All	0.883	1.000	<.001	36	view →
KICH	OS	Median	All	0.691	1.000	.004	29	view →
UCEC	OS	Median	All	0.833	0.909	.001	22	view →
MESO	OS	Tertile	III,IV	0.833	0.309	.006	21	view →
KIRC	DFS	Quartile	All	0.574	0.705	.009	19	view →
OV	OS	Quartile	III,IV	0.281	0.378	.027	18	view →
HNSC	DFS	Quartile	IV	0.759	0.562	.007	17	view →
SKCM	OS	Quartile	All	0.922	0.827	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PRDM6–UVM (DFS)

Open the UVM breakdown →