PRB4

Across TCGA cell cohorts, PRB4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRB4-associated genes across cancer lineages are MAGEB5, SHCBP1L, and HMHB1. Each is linked with PRB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB4-to-partner and partner-to-PRB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by PRB4-low versus PRB4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB4→partner) and Y-score (partner→PRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
SKIN	SHCBP1L →	+0.036	+3.345	<.001	.007	3	1
SKIN	HMHB1 →	+0.038	+4.022	<.001	.006	3	1
SKIN	H4C12 →	+1.168	+3.688	<.001	.002	3	1
LARGE_INTESTINE	CD2 →	+0.031	+4.347	<.001	.001	3	1
LARGE_INTESTINE	OR1Q1 →	+0.363	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MAGEB5 by PRB4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →