PRB4

Across TCGA pan-cancer cohorts, PRB4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PRB4 data layer compared with 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PRB4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRB4 expression acts as an unfavorable survival marker, although some lineages such as THYM and LIHC show a favorable association.

LUAD, THCA, and MESO are the cancer types where PRB4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.317	0.741	<.001	98	view →
THCA	DFS	Tertile	All	0.770	0.910	<.001	72	view →
MESO	DFS	Tertile	All	0.218	0.420	.006	63	view →
ACC	DFS	Quartile	II,III,IV	0.213	0.673	<.001	51	view →
THYM	DFS	Tertile	All	0.981	0.798	.004	31	view →
STAD	DFS	Tertile	II,III,IV	0.271	0.543	.013	22	view →
KIRP	OS	Tertile	II,III,IV	0.141	0.673	.017	21	view →
KIRC	DFS	Tertile	All	0.608	0.830	<.001	18	view →
TGCT	DFS	Tertile	All	0.517	0.734	.016	18	view →
READ	DFS	Tertile	All	0.661	0.869	.010	18	view →
KICH	DFS	Tertile	IV	0.317	0.923	.038	18	view →
LIHC	OS	Tertile	All	0.944	0.593	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PRB4–LUAD (OS)

Open the LUAD breakdown →