PRB4

Across TCGA pan-cancer cohorts, PRB4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRB4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRB4 RNA is repressed in tumor relative to normal tissue. In most cancer types PRB4 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, BRCA, and LUAD are the cancer types where PRB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−1.371	.002	4	view →
BRCA	Female	All	+0.111	.038	2	view →
LUAD	All	All	+0.215	.018	1	view →
KICH	Female	All	+0.046	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRB4–HNSC

Open the HNSC breakdown →