PRB2

Across TCGA cell cohorts, PRB2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRB2-associated genes across cancer lineages are CRX, OR5B12, and BPIFB3. Each is linked with PRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB2-to-partner and partner-to-PRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRX grouped by PRB2-low versus PRB2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB2→partner) and Y-score (partner→PRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRX →	+0.004	+3.345	<.001	.007	3	1
SKIN	OR5B12 →	+0.032	+3.854	.004	.006	3	1
SKIN	BPIFB3 →	+0.015	+4.022	<.001	.006	3	1
SKIN	USP17L17 →	+0.006	+4.022	<.001	.006	3	1
LUNG_SCLC	PRAMEF6 →	+0.016	+5.029	<.001	.006	3	1
LARGE_INTESTINE	TIFAB →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CRX by PRB2 expression — SKIN

Explore this box plot interactively →