PRB2

Across TCGA pan-cancer cohorts, PRB2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRB2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PRB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRB2 is over-expressed in tumor.

LUSC, KICH, and BRCA are the cancer types where PRB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.232	.001	4	view →
KICH	All	All	+0.479	.011	3	view →
BRCA	Female	All	+0.071	.028	2	view →
LUAD	All	All	+0.087	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRB2–LUSC

Open the LUSC breakdown →