PRB2

Across TCGA pan-cancer cohorts, PRB2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PRB2 data layer compared with 7 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PRB2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRB2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

BLCA, MESO, and KIRP are the cancer types where PRB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.431	0.584	<.001	71	view →
MESO	OS	Median	III,IV	0.417	0.647	<.001	64	view →
KIRP	DFS	Tertile	II,III,IV	0.173	0.940	<.001	60	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	50	view →
HNSC	DFS	Tertile	IV	0.447	0.257	.009	35	view →
UVM	OS	Median	III,IV	0.246	0.836	.003	33	view →
THCA	OS	Tertile	All	0.959	1.000	.006	24	view →
UCEC	DFS	Quartile	All	0.737	0.862	<.001	22	view →
COAD	DFS	Quartile	II,III,IV	0.468	0.744	.011	17	view →
LGG	DFS	Tertile	All	0.898	0.768	.001	14	view →
PCPG	DFS	Tertile	All	0.471	0.895	.018	8	view →
PAAD	OS	Median	All	0.549	0.674	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PRB2–BLCA (DFS)

Open the BLCA breakdown →