PRAMEF6

Across TCGA patient cohorts, PRAMEF6 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF6-associated genes across cancer lineages are RNU4-58P, RNY4P27, and RNY4P16. Each is linked with PRAMEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF6-to-partner and partner-to-PRAMEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by PRAMEF6-low versus PRAMEF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF6→partner) and Y-score (partner→PRAMEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.262	+3.133	.003	.009	3	1
UCEC	RNY4P27 →	+0.284	+4.453	<.001	<.001	3	1
UCEC	RNY4P16 →	+0.277	+4.069	<.001	.008	3	1
UCEC	SNORA36C →	+0.280	+3.551	<.001	.004	3	1
UCEC	TRBJ2-2 →	+1.228	+3.950	.004	.001	3	1
UCEC	TRAJ57 →	+0.672	+2.997	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

RNU4-58P by PRAMEF6 expression — UCEC

Explore this box plot interactively →