PPP5C

Across TCGA patient cohorts, PPP5C mutation is significantly associated with the RNA expression of many other genes, with 1,162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP5C-associated genes across cancer lineages are MIR6766, VN1R90P, and LINC02559. Each is linked with PPP5C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP5C-to-partner and partner-to-PPP5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6766 grouped by PPP5C-low versus PPP5C-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP5C→partner) and Y-score (partner→PPP5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6766 →	+0.544	+5.575	<.001	.004	3	2
STAD	VN1R90P →	+0.683	+3.620	<.001	.008	3	2
CESC	LINC02559 →	+1.329	+5.342	<.001	.002	3	2
CESC	KRTAP19-7 →	+0.076	+6.584	<.001	<.001	3	2
LIHC	IGKJ5 →	+1.786	+3.705	<.001	.004	3	2
BRCA	MT-TD →	+0.578	+5.506	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,162 associations by consensus.

MIR6766 by PPP5C expression — BRCA

Explore this box plot interactively →