PPP5C

Across TCGA pan-cancer cohorts, PPP5C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPP5C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP5C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP5C is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where PPP5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.577	<.001	11	view →
COAD	Female	All	+0.914	<.001	10	view →
BLCA	Female	All	+0.774	<.001	10	view →
LIHC	All	II,III,IV	+0.720	<.001	8	view →
THCA	Female	All	+0.336	<.001	7	view →
STAD	Male	II,III,IV	+0.895	<.001	6	view →
BRCA	All	III,IV	+0.585	<.001	6	view →
CHOL	Male	All	+1.956	<.001	5	view →
KICH	All	All	−0.502	<.001	5	view →
ESCA	All	All	+0.825	<.001	4	view →
KIRP	Female	II,III,IV	+0.618	.008	4	view →
LUSC	Male	All	+0.484	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPP5C–HNSC

Open the HNSC breakdown →