PPP5C

Across TCGA pan-cancer cohorts, PPP5C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PPP5C data layer compared with 4 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPP5C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP5C expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

UVM, MESO, and LIHC are the cancer types where PPP5C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.326	0.664	<.001	124	view →
MESO	OS	Median	II,III,IV	0.447	0.659	<.001	100	view →
LIHC	OS	Median	All	0.605	0.787	<.001	57	view →
LGG	DFS	Median	All	0.641	0.843	<.001	51	view →
SCLC	OS	Median	All	0.779	0.515	.003	48	view →
ACC	OS	Median	All	0.770	0.973	.001	41	view →
KICH	DFS	Tertile	III,IV	0.282	0.931	.003	36	view →
LUSC	DFS	Median	III,IV	0.251	0.519	.003	21	view →
UCEC	DFS	Quartile	IV	0.858	0.301	.017	16	view →
THCA	OS	Median	III,IV	1.000	0.906	.006	15	view →
ESCA	DFS	Tertile	III,IV	0.261	0.499	.017	15	view →
HNSC	OS	Median	All	0.296	0.486	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PPP5C–UVM (DFS)

Open the UVM breakdown →