PPP1R15B

Across TCGA patient cohorts, PPP1R15B mutation is significantly associated with the RNA expression of many other genes, with 3,761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R15B-associated genes across cancer lineages are PRPF19P1, CDRT15P8, and RNA5SP294. Each is linked with PPP1R15B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R15B-to-partner and partner-to-PPP1R15B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRPF19P1 grouped by PPP1R15B-low versus PPP1R15B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15B→partner) and Y-score (partner→PPP1R15B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PRPF19P1 →	+0.128	+4.566	<.001	<.001	3	3
READ	CDRT15P8 →	+0.125	+5.421	<.001	.005	3	2
CESC	RNA5SP294 →	+0.342	+5.103	<.001	.008	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
UCEC	RNA5SP411 →	+0.740	+2.015	.004	.001	3	2
SKCM	MRGPRX6P →	+0.052	+4.884	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,761 associations by consensus.

PRPF19P1 by PPP1R15B expression — LUSC

Explore this box plot interactively →