PPP1R15B

Across TCGA pan-cancer cohorts, PPP1R15B RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PPP1R15B data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPP1R15B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R15B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRP, KIRC, and CESC are the cancer types where PPP1R15B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.846	0.969	<.001	112	view →
KIRC	OS	Median	All	0.696	0.561	<.001	111	view →
CESC	DFS	Tertile	All	0.399	0.688	<.001	82	view →
UVM	DFS	Quartile	All	0.228	0.773	.001	54	view →
UCS	OS	Quartile	II,III,IV	0.786	0.284	<.001	30	view →
ACC	DFS	Quartile	All	0.217	0.807	.001	22	view →
UCEC	DFS	Quartile	All	0.787	0.903	.002	20	view →
KICH	OS	Median	II,III,IV	0.789	0.969	.005	18	view →
BLCA	OS	Quartile	II,III,IV	0.497	0.637	.027	18	view →
CHOL	DFS	Tertile	All	0.792	0.102	.004	15	view →
LGG	OS	Quartile	All	0.753	0.981	<.001	13	view →
HNSC	DFS	Quartile	IV	0.744	0.549	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PPP1R15B–KIRP (DFS)

Open the KIRP breakdown →